2023
LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein. FASEB J. 2023 Jul;37(7):e23028. PMID: 37310356
Mustafa Balkaya, Preeti Dohare, Sophie Chen, Alexandra L. Schober, Antonio M. Fidaleo, Julia W. Nalwalk, Rajan Sah, Alexander A. Mongin. Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release. iScience. 2023 Apr 14;26(5):106669. PMID: 37182109
Zhihui He, Yonghui Zhao, Michael J. Rau, James A.J. Fitzpatrick, Rajan Sah, Hongzhen Hu, Peng Yuan Structural and functional analysis of human pannexin 2 channel. Nat Commun. 2023 Mar 27;14(1):1712. PMID: 36973289
Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah. Adipose-targeted SWELL1 deletion exacerbates obesity- And age-related nonalcoholic fatty liver disease. JCI Insight. 2023 Mar 8;8(5):e154940. PMID: 36749637
Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy. ASN Neuro. 2023 Jan-Dec;15:17590914231184072. PMID: 37410995
2022
Gunasekar, S.K., Xie, L., Chheda, P.R., Kang, C., Kern, D. M., My-Ta, C., Kumar, A., Maurer, J.M., Gerber, E.E., Grzesik, W.J., Elliot-Hudson, M., Zhang, Y., Kulkarni, C.A. Samuel, I., Smith, J.K., Nau, P., Imai, Y., Sheldon, R., Taylor, E.B., Lerner, D.J., Norris, A.W., Klein, S., Brohawn, S.G., Kerns, R., Sah, R. Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nature Communications 10 Feb 2022 13, 784. PMID: 35145074 PMC8831520 DOI: 10.1038/s41467-022-28435-0
Park, L.K., Garr-Barry, V., Hong, J., Heebink, J., Sah, R., Peterson, L.R., Links between ceramides and cardiac function. Curr Opin Lipidol 01 Feb 2022. PMID: 34889803
2021
Lan Z, Chen L, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H. The mechanosensitive TRPV4 is required for crystal-induced inflammation. Ann Rheum Dis 2021. PMID: 34663597.
Wilson CS, Dohare P, Orbeta S, Nalwalk JW, Huang Y, Ferland RJ, Sah R, Scimemi A, Mongin AA. Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A. FASEB Journal 01 Sept 2021. doi: 10.1096/fj.202002745R.
Turner D, Kang C, Mesirca P, Hong J, Magnoni ME, Glukhov AV, Sah R. Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity.Front Cardiovasc Med. 2021 Aug 9;8:662410. doi: 10.3389/fcvm.2021.662410. PMID: 34434970
Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity 2021 Jul 21:S1074-7613(21)00289-2. doi: 10.1016/j.immuni.2021.07.003. Epub ahead of print. PMID: 34320366.
MishraLiu Sivitz FinkBhardwaj O’NeillKangStephensKingJacksonAnokye-Danso AnkrumImaiPerilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. JCI Insight 2021: Mar 30;144341: PMID:33784258
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function. Elife. 2021 Feb 25;10:e61313.
2020
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover TL, Chou J, Geha R, Benavides F, Hume RI and Xu H. LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. Proc Natl Acad Sci U S A.
Kumar A, Xie L, My-Ta C, Hinton AJ, Gunasekar S, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer GA and Sah R. SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism. Elife. 2020 Sep 15;9:e58941. doi: 10.7554/eLife.58941.
Grimes D, Johnson, R, Pashos M, Cummings C, Kang C, Sampedro, GR, Tycksen, E, McBride H.J., Sah R, Lowell, CA, Clemens RA., ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 Sep 14:202008032. doi: 10.1073/pnas.2008032117.
Zhou JJ, Luo Y, Chen SR, Shao JY, Sah R and Pan HL.LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons.Exp Neurol. 2020 Oct;332:113391. doi: 10.1016/j.expneurol.2020.113391.
2019
Gunasekar SK, Xie L, Sah R. SWELL signalling in adipocytes: can fat ‘feel’ fat? Adipocyte. 2019 Dec;8(1):223-228. doi: 10.1080/21623945.2019. Epub 21 May 2019. PMID: 31112068
Menegaz D, Hagan DW, Almaça J, Cianciaruso C, Rodriguez-Diaz R, Molina J, Becker MW, Dolan RM, Schwalie PC, Nano R, Lebreton F, Kang C, Sah R, Gaisano HY, Berggren P-O, Baekkeskov S, Caicedo A, and Phelps EA. Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nature Metabolism. 2019 Nov;1, 1110–1126 (2019).
2018
Kang C, Xie L, Gunasekar SK, Mishra A, Zhang Y, Pai S, Gao Y, Kumar A, Norris AW, Stephens SB, Sah R. SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia. Nat Commun. 2018 Jan 25;9(1):367. doi: 10.1038/s41467-017-02664-0. PMID: 29371604
2017
Xie L, Zhang Y, Gunasekar S, Mishra A, Cao L, Sah R. Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity. Channels(Austin). 2017 Nov 2;11(6):673-677. doi: 10.1080/19336950.2017.1373225. Epub 2017 Oct 5. PMID: 28873008
Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6079-E6088. pii: 201707380. doi: 10.1073/pnas.1707380114. Epub 2017 Jul 10. PMID: 28696294
Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Dale Abel E, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May;19(5):504-517. doi: 10.1038/ncb3514. Epub 2017 Apr 24. PMID: 28436964
Wang R, Lu Y, Gunasekar S, Zhang Y, Benson CJ, Chapleau MW, Sah R, Abboud FM. The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH. JCI Insight.2017 Mar 9;2(5):e90632. doi: 10.1172/jci.insight.90632. PMID: 28289711
Zhang Y, Tong D, Mishra A, Xie L, Samuel I, Smith JK, Sah R. Isolation and Patch-Clamp of Primary Adipocytes. in Thermogenic Fat: Methods and Protocols. Methods Molecular Biology. 2017;1566:145-150. doi: 10.1007/978-1-4939-6820-6_14. PMID: 28244048
2016
Fatima U, Gupta S, Firchau DJ, Stolpen AH, Sah R. A Rare Pericardial Malignancy. Circ Heart Fail. 2016 Jul;9(7). pii: e003282. doi: 10.1161/CIRCHEARTFAILURE.116.003282. PMID: 27413030
2013
Sah, R., Mesirca, P., Van den Boogert, M., Rosen, J., Mably, J., Mangoni, M. & Clapham, D. (2013). Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.Proc Natl Acad Sci USA, 110(32), E3037-3046. PMID: 23878236
Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.Circulation. 2013 Jul 9;128(2):101-14. doi: 10.1161/CIRCULATIONAHA.112.000768. PMID: 23734001
2012
Ye, L., Kleiner, S., Wu, J., Sah, R., Gupta, R., Banks, A., Sah, R., Cohen, P., Khandekar, M., Boström, P., Mepani, R., Laznik, D., Kamenecka, T., Song, X., Liedtke, W., Mootha, V., Puigserver, P., Griffin, P., Clapham, D. & Spiegelman, B. (2012). TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell, 151(1), 96-110.
PMID: 23021218
2011
Ramirez, R. J., Sah, R., Liu, J., Rose, R. A. & Backx, P. H. (2011). Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials.Basic Res Cardiol., 106(6), 967-77.
PMID: 21779914
Bates-Withers, C., Sah, R. & Clapham, D. E. (2011). TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol., 704, 173-83. PMID: 21290295
2007
Sah, R., Epstein, L. M. & Kwong, R. Y. (2007). Images in cardiovascular medicine. Intramural atrial hematoma after catheter ablation for atrial tachyarrhythmias. Circulation, 115(18), e446-7. PMID: 17485585
2006
Trivieri, M. G., Oudit, G. Y., Sah, R., Kerfant, B. G., Sun, H., Gramolini, A. O., Pan, Y., Wickenden, A. D., Croteau, W., Morreale de Escobar, G., Pekhletski, R., St Germain, D., Maclennan, D. H. & Backx, P. H. (2006). Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A., 103(15), 6043-8. PMID: 16595628
2003
Sah, R., Ramirez, R. J., Oudit, G. Y., Gidrewicz, D., Trivieri, M. G., Zobel, C. & Backx, P. H. (2003). Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol. , 546(Pt 1), 5-18.
PMID: 12509475
2002
Kaprielian, R., Sah, R., Nguyen, T., Wickenden, A. D. & Backx, P. H. (2002). Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1157-68.
PMID: 12181147
Sah, R., Ramirez, R. J. & Backx, P. H. (2002). Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ Res. 2002 Feb 8;90(2):165-73. PMID: 11834709
Sah, R., Oudit, G. Y., Nguyen, T. T., Lim, H. W., Wickenden, A. D., Wilson, G. J., Molkentin, J. D. & Backx, P. H. (2002). Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation, 105(15), 1850-6. PMID: 11956130
Crackower, M. A., Oudit, G. Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J., Sah, R., Cheng, H. Y., Rybin, V. O., Lembo, G., Fratta, L., Oliveira-dos-Santos, A. J., Benovic, J. L., Kahn, C. R., Izumo, S., Steinberg, S. F., Wymann, M. P., Backx, P. H. & Penninger, J. M. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell, 110(6), 737-49. PMID: 12297047
2001
Oudit, G. Y., Kassiri, Z., Sah, R., Ramirez, R. J., Zobel, C. & Backx, P. H. (2001). The molecular physiology of the cardiac transient outward potassium current (Ito) in normal and diseased myocardium. J Mol Cell Cardiol, 33, 851-72. PMID: 11343410
Sah, R., Ramirez, R. J., Kaprielian, R. & Backx, P. H. (2001). Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. J Physiol. 533(Pt 1), 201-14. PMID: 11351028
1999
Wickenden, A. D., Lee, P., Sah, R., Fishman, G. I. & Backx, P. H. (1999). Targeted expression of a Kv4.2 dominant-negative Subunit in the mouse heart. Circ Res, 85, 1067-76. PMID: 10571538
1998
Sah, R. L., Tsushima, R. G. & Backx, P. H. (1998). Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation. Am J Physiol. 275(2 Pt 1), C389-400. PMID: 9688593
1996
Hanna, W. J., Tsushima, R. G., Sah, R., McCutcheon, L. J., Marban, E. & Backx, P. H. (1996). The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states. J Physiol. 1996 Dec 1;497 ( Pt 2):349-64. PMID: 8961180