Kumar A, Xie L, My-Ta C, Hinton AJ, Gunasekar S, Minerath RA, Shen K, Maurer JM, Grueter CE, Abel ED, Meyer GA and Sah R. SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism. Elife. 2020 Sep 15;9:e58941. doi: 10.7554/eLife.58941.

Grimes D, Johnson, R, Pashos M, Cummings C, Kang C, Sampedro, GR, Tycksen, E, McBride H.J., Sah R, Lowell, CA, Clemens RA., ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 Sep 14:202008032. doi: 10.1073/pnas.2008032117.

Zhou JJ, Luo Y, Chen SR, Shao JY, Sah R and Pan HL. LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons. Exp Neurol. 2020 Oct;332:113391. doi: 10.1016/j.expneurol.2020.113391. 


Gunasekar SK, Xie L, Sah R. SWELL signalling in adipocytes: can fat ‘feel’ fat?
Adipocyte. 2019 Dec;8(1):223-228. doi: 10.1080/21623945.2019. Epub 21 May 2019

Menegaz D, Hagan DW, Almaça J, Cianciaruso C, Rodriguez-Diaz R, Molina J, Becker MW, Dolan RM, Schwalie PC, Nano R, Lebreton F, Kang C,  Sah R, Gaisano HY, Berggren P-O, Baekkeskov S, Caicedo A, and Phelps EA. Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell. Nature Metabolism. 2019 Nov;1, 1110–1126 (2019).


Kang C, Xie L, Gunasekar SK, Mishra A, Zhang Y, Pai S, Gao Y, Kumar A, Norris AW, Stephens SB, Sah R. SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia. Nat Commun. 2018 Jan 25;9(1):367. doi: 10.1038/s41467-017-02664-0.
PMID: 29371604


Xie L, Zhang Y, Gunasekar S, Mishra A, Cao L, Sah RInduction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity.  Channels(Austin). 2017 Nov 2;11(6):673-677. doi: 10.1080/19336950.2017.1373225. Epub 2017 Oct 5.
PMID: 28873008

Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles.  Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6079-E6088. pii: 201707380. doi: 10.1073/pnas.1707380114. Epub 2017 Jul 10.
PMID: 28696294

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Dale Abel E, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May;19(5):504-517. doi: 10.1038/ncb3514. Epub 2017 Apr 24.
PMID: 28436964
Science Daily  |  Noon News

Wang R, Lu Y, Gunasekar S, Zhang Y, Benson CJ, Chapleau MW, Sah R, Abboud FM.  The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH. JCI Insight. 2017 Mar 9;2(5):e90632. doi: 10.1172/jci.insight.90632.
PMID: 28289711

Zhang Y, Tong D, Mishra A, Xie L, Samuel I, Smith JK, Sah R. Isolation and Patch-Clamp of Primary Adipocytes. in Thermogenic Fat: Methods and Protocols. Methods Molecular Biology. 2017;1566:145-150. doi: 10.1007/978-1-4939-6820-6_14.


Fatima U, Gupta S, Firchau DJ, Stolpen AH, Sah R. A Rare Pericardial Malignancy. Circ Heart Fail. 2016 Jul;9(7). pii: e003282. doi: 10.1161/CIRCHEARTFAILURE.116.003282.
PMID: 27413030


Sah, R., Mesirca, P., Van den Boogert, M., Rosen, J., Mably, J., Mangoni, M. & Clapham, D. (2013). Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci USA, 110(32), E3037-3046.
PMID: 23878236

Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 2013 Jul 9;128(2):101-14. doi: 10.1161/CIRCULATIONAHA.112.000768.
PMID: 23734001


Ye, L., Kleiner, S., Wu, J., Sah, R., Gupta, R., Banks, A., Sah, R., Cohen, P., Khandekar, M., Boström, P., Mepani, R., Laznik, D., Kamenecka, T., Song, X., Liedtke, W., Mootha, V., Puigserver, P., Griffin, P., Clapham, D. & Spiegelman, B. (2012). TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell, 151(1), 96-110.
PMID: 23021218


Ramirez, R. J., Sah, R., Liu, J., Rose, R. A. & Backx, P. H. (2011). Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials. Basic Res Cardiol., 106(6), 967-77.
PMID: 21779914

Bates-Withers, C., Sah, R. & Clapham, D. E. (2011). TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol., 704, 173-83.
PMID: 21290295


Sah, R., Epstein, L. M. & Kwong, R. Y. (2007). Images in cardiovascular medicine. Intramural atrial hematoma after catheter ablation for atrial tachyarrhythmias. Circulation, 115(18), e446-7.
PMID: 17485585


Trivieri, M. G., Oudit, G. Y., Sah, R., Kerfant, B. G., Sun, H., Gramolini, A. O., Pan, Y., Wickenden, A. D., Croteau, W., Morreale de Escobar, G., Pekhletski, R., St Germain, D., Maclennan, D. H. & Backx, P. H. (2006). Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A. , 103(15), 6043-8.
PMID: 16595628


Sah, R., Ramirez, R. J., Oudit, G. Y., Gidrewicz, D., Trivieri, M. G., Zobel, C. & Backx, P. H. (2003). Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol. , 546(Pt 1), 5-18.
PMID: 12509475


Kaprielian, R., Sah, R., Nguyen, T., Wickenden, A. D. & Backx, P. H. (2002). Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. Am J Physiol Heart Circ Physiol.  2002 Sep;283(3):H1157-68.
 PMID: 12181147

Sah, R., Ramirez, R. J. & Backx, P. H. (2002). Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ Res. 2002 Feb 8;90(2):165-73.
PMID: 11834709

Sah, R., Oudit, G. Y., Nguyen, T. T., Lim, H. W., Wickenden, A. D., Wilson, G. J., Molkentin, J. D. & Backx, P. H. (2002). Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation, 105(15), 1850-6.
PMID: 11956130

Crackower, M. A., Oudit, G. Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J., Sah, R., Cheng, H. Y., Rybin, V. O., Lembo, G., Fratta, L., Oliveira-dos-Santos, A. J., Benovic, J. L., Kahn, C. R., Izumo, S., Steinberg, S. F., Wymann, M. P., Backx, P. H. & Penninger, J. M. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell, 110(6), 737-49.
 PMID: 12297047


Oudit, G. Y., Kassiri, Z., Sah, R., Ramirez, R. J., Zobel, C. & Backx, P. H. (2001). The molecular physiology of the cardiac transient outward potassium current (Ito) in normal and diseased myocardium. J Mol Cell Cardiol, 33, 851-72.
 PMID: 11343410

Sah, R., Ramirez, R. J., Kaprielian, R. & Backx, P. H. (2001). Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. J Physiol.  533(Pt 1), 201-14.
PMID: 11351028


Wickenden, A. D., Lee, P., Sah, R., Fishman, G. I. & Backx, P. H. (1999). Targeted expression of a Kv4.2 dominant-negative Subunit in the mouse heart. Circ Res, 85, 1067-76.
PMID: 10571538


Sah, R. L., Tsushima, R. G. & Backx, P. H. (1998). Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation. Am J Physiol.  275(2 Pt 1), C389-400.
PMID: 9688593


Hanna, W. J., Tsushima, R. G., Sah, R., McCutcheon, L. J., Marban, E. & Backx, P. H. (1996). The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states. J Physiol. 1996 Dec 1;497 ( Pt 2):349-64.
PMID: 8961180

View all of Rajan Sah’s publications on PubMed.gov »